Yes — AuraGene is completely free, requires no login, and stores nothing on a server. It runs entirely in your browser.

What can I search for?

Search by gene symbol (e.g. CFTR, HTT, BRCA1), variant rsID (e.g. rs113993960), or genomic coordinate (e.g. 11:5227002:A:T). The tool resolves your query to the most relevant rare disease, loads the 3D structure, and shows clinical trials and therapies.

Does AuraGene replace medical advice?

No. AuraGene aggregates publicly available data from Ensembl, UniProt, ClinicalTrials.gov, OpenTargets and HPO. It does not provide a diagnosis. Always consult a qualified specialist for medical decisions.

What languages does it support?

Native English and German user interface plus 35+ additional languages via on-demand Google Translate. Patient-friendly explanations are curated in both English and German for all 26 catalog diseases.

Which rare diseases are in the catalog?

26 curated entries including Cystic Fibrosis (CFTR), Huntington's Disease (HTT), Gaucher Disease (GBA), Sickle Cell Anemia (HBB), Alzheimer's (APP), Duchenne Muscular Dystrophy (DMD), Spinal Muscular Atrophy (SMN1), Marfan Syndrome (FBN1), Wilson Disease (ATP7B), Pompe (GAA), Fabry (GLA), Tay-Sachs (HEXA), ALS-SOD1, Friedreich Ataxia (FXN), Rett Syndrome (MECP2), Neurofibromatosis (NF1), PKU (PAH), Galactosemia (GALT), Achondroplasia (FGFR3), Vascular Ehlers-Danlos (COL3A1), Von Hippel-Lindau (VHL), Hereditary Breast/Ovarian Cancer (BRCA1), Polycystic Kidney Disease (PKD1), Familial Hypercholesterolemia (LDLR), Familial Prion Disease (PRNP) and Li-Fraumeni Syndrome (TP53).

AuraGene — Free Rare Disease & Genetic Variant Explorer (Patient Mode + 3D + 26 Diseases)

info

Biological Summary

Cystic Fibrosis

GENE: CFTR

Cystic fibrosis transmembrane conductance regulator

description Biological Function

Epithelial anion channel that plays an essential role in regulating systemic fluid flow and water balance across epithelia.

cell_merge Subcellular Location

Extracellular Space

Cytoplasm

Apical cell membrane, Multi-pass membrane protein

auto_stories Was bedeutet das?

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lightbulb

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Typische Symptome

Reading level

view_in_ar

3D Molecular Structure

PDB Source: 1CLL

vaccines

Therapeutics & Trials

Active Clinical Trials

0 Active

clinical_trials

Querying clinical nodes...

Associated Compounds

science

Ivacaftor (VX-770) CFTR Potentiator

science

Lumacaftor (VX-809) CFTR Corrector

Symptom-Suche (HPO)

Unterstützung & Selbsthilfe

Fragen für den Arztbesuch

dna

Pathogenic Mutations & ClinVar Evidence

Genetische Varianten — Verständlich

Variant ID (dbSNP)	Genomic Location	Consequence	Codon Change	ClinVar Clinical Significance	Action

Hinweis: Klicke im 3D-Modell auf eine Variante, um den betroffenen Baustein hervorgehoben zu sehen. Frage deine Ärztin / deinen Arzt, was die Befunde für dich konkret bedeuten.

AuraGene

At-a-Glance

Biological Summary

Cystic Fibrosis

description Biological Function

cell_merge Subcellular Location

auto_stories Was bedeutet das?

Typische Symptome

accessibility_new Wo im Körper wirkt das?

3D Molecular Structure

…

Therapeutics & Trials

Active Clinical Trials

Associated Compounds

Symptom-Suche (HPO)

Unterstützung & Selbsthilfe

Fragen für den Arztbesuch

Pathogenic Mutations & ClinVar Evidence

Genetische Varianten — Verständlich

At-a-Glance

Biological Summary

Cystic Fibrosis

description Biological Function

cell_merge Subcellular Location

auto_stories Was bedeutet das? volume_up

Typische Symptome

accessibility_new Wo im Körper wirkt das?

3D Molecular Structure

…

Therapeutics & Trials

Active Clinical Trials

Associated Compounds

Symptom-Suche (HPO)

Unterstützung & Selbsthilfe

Fragen für den Arztbesuch

Pathogenic Mutations & ClinVar Evidence

Genetische Varianten — Verständlich

auto_stories Was bedeutet das?